Veterinary Wound Healing Association 5th Congress, Hannover, Germany. May 10-12 2001
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| THE USE OF PORCINE SMALL INTESTINAL SUBMUCOSAL (SIS) GRAFTS IN RECONSTRUCTIVE SURGERY Donald E Sheahan BVSc BSc Cert SAS MRCVS; D. Crossley FAVD Dip EVDC MRCVS Animal Medical Center Referral Services 511 Wilbraham Rd Chorlton-cum-Hardy Manchester M21 0UB SIS is a novel biomaterial, derived from porcine small intestinal submucosa, which allows smart tissue remodeling. Initial research in vascular graft studies demonstrated that SIS could support the controlled proliferation of relatively specialized tissues such as smooth muscle and endothelial cells. These studies also demonstrated that SIS is accepted by the recipient host without eliciting an adverse immunological response and that the connective tissue remodeling is responsive to local body stressors and appropriate to the microenvironment in which it is placed. This paper illustrates the initial clinical experiences of the authors using porcine small intestinal submucosal grafts to repair large tissue deficits. SIS was used in eight clinical cases to repair either congenital tissue defects or tissue defects created following oncological resection. In all cases the SIS graft allowed appropriate tissue remodeling with minimal immunolgical response or scar tissue formation. Return to index of Abstracts | About the VWHA |