Veterinary Wound Healing Association 5th Congress, Hannover, Germany. May 10-12 2001
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| MALP-2, A SYNTHETIC LIPOPEPTIDE, MAY BE USEFUL FOR ACCELERATING WOUND HEALING AND INHIBITING WOUND INFECTION. Peter F. Mühlradt, Ursula Deiters, and Michael Morr Gesellschaft für Biotechnologische Forschung mbH., Mascheroder Weg 1, D-38124-Braunschweig, Germany. MALP-2 is a lipopeptide which was originally isolated from mycoplasmas on account of its capacity to stimulate macrophages. It is now synthetically available. MALP-2 acts in µg quantities upon i.c. injection, causing infiltration of leukocytes in mouse and humans. Leukocyte infiltration is mediated by chemokine release from skin macrophages, fibroblasts and possibly other cells. First PMNs arrive at the site of injection, followed by macrophages. Since macrophages are the source of virtually all relevant growth factors involved in wound healing, we are presently testing MALP-2 in a full incision punch biopsy wound model in diabetic mice. Wounds are covered by transparent dressings and MALP-2 is injected into the wound bed. After 3 days leukocyte infiltration is noticeable, followed by a thin cover of fibroblasts. This fibroblast layer is formed more rapidly in MALP-2-treated wounds than in control wounds. Also wound closure is accelerated. We think that MALP-2 may also be useful in preventing wound infection because of its leukocyte attracting and activating properties. Return to index of Abstracts | About the VWHA |