Veterinary Wound Healing Association 5th Congress, Hannover, Germany. May 10-12 2001
| Return to index of Abstracts | About the VWHA |
| SULFONATED SHALE OILS IN WOUND HEALING Dr. Guido Gayko Ichthyol-Gesellschaft, Sportallee 85, 22335 Hamburg Sulfonated Shale Oils are active substances of natural origin. The antimicrobial and antiinflammatory effects of sulfonated shale oils (e.g. ICHTHAMMOL®) have been substantiated in numerous in-vitro as well as in-vivo studies. Recently, pale sulfonated shale oil (ICHTHO®-VET) was investigated with regard to its wound healing properties. By addition of aqueous solutions of pale sulfonated shale oil to transformed immortalized cultures of ceratinocytes (HaCaT) in vitro a 20% increase in the number of cells could be observed in comparison with a control without active substance. In a second investigation in human cultures of ceratinocytes the exprimation of the platelet-derived growth factor PDGF-AB by HaCaT cells was significantly increased in presence of the active substance. The clinical efficacy of a gel formulation containing 10% pale sulfonated shale oil was investigated in different studies on humans. As could be shown, all germs relevant in wound infection are opposed with this formulation including methicilline-resistant Staphylococcus aureus (MRSA). In a study comparing the antibacterial effects and wound healing properties of this formulation with those of a commercially available preparation containing PVP-Iodine granulation and epitheliazation was observed to be enhanced by up to 30% with the sulfonated shale oil product at comparable antibacterial efficacy. Different case studies show that pale sulfonated shale oil is suitable for the treatment of wounds after excision of skin tumors. Other case studies prove that it is applied successfully to ulcera resistant to therapy with other topical preparations. Return to index of Abstracts | About the VWHA |