Veterinary Wound Healing Association 5th Congress, Hannover, Germany. May 10-12 2001
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| EFFECTS OF A HYDROLYZED COLLAGEN DRESSING ON THE HEALING OF OPEN WOUNDS IN DOGS S.F. Swaim, R.L. Gillette, E.A. Sartin, S.H. Hinkle, S.L. Coolman Wound Healing/Reconstructive Surgery Program, Scott-Ritchey Research Center (Swaim, Gillette, Hinkle, Coolman) and The Department of Pathobiology (Sartin), College of Veterinary Medicine, Auburn University, AL 36849 The study objective was to determine the effects of a hydrolyzed bovine collagen dressing (HBCD) on the healing of open wounds in healthy dogs. Two full-thickness skin wounds were made bilaterally on the trunk of each dog. On one side wounds were treated with powdered HBCD covered with a semiocclusive nonadherent bandage only. Wound healing was assessed subjectively. In addition, the percentage increase in perfusion of the tissues was evaluated by laser Doppler perfusion imaging (LDPI). Planimetry was used to determine the percentage of change in wound contraction, epithelialization and total wound healing. Histologic changes were evaluated from biopsy specimens from the wounds. The HBCD did not cause a strong inflammatory reaction as shown by LDPI and histologic results. It appeared to be hydrophilic, providing a moist environment to keep wounds clean and enhance early epithelialization. Seven days after treatment started, treated wounds had significantly greater percentage of epithelialization than control wounds (12.13 vs. 7.03%). It was concluded that the hydrophilic property of HBCD may cleanse contaminated wounds with the body's own homeostatic fluids and enhance early wound epithelialization. This study was supported by KenVet, Division of Loveland Industries, Inc., Greeley, Colorado. Return to index of Abstracts | About the VWHA |